Identification and characterization of functional long noncoding RNAs in cancer
| Autor: | Christiane E. Olivero, Nadya Dimitrova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Carcinogenesis Disease Computational biology Biology Biochemistry Epigenesis Genetic 03 medical and health sciences lncRNA 0302 clinical medicine Neoplasms Genetics medicine Animals Humans cancer Molecular Biology function Cancer medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Invited Article Biological significance identification RNA Long Noncoding Identification (biology) GEMMs 030217 neurology & neurosurgery Function (biology) Biotechnology |
| Zdroj: | The FASEB Journal |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.202001951r |
| Popis: | Long noncoding RNAs (lncRNAs) have emerged as key regulators in a variety of cellular processes that influence disease states. In particular, many lncRNAs are genetically or epigenetically deregulated in cancer. However, whether lncRNA alterations are passengers acquired during cancer progression or can act as tumorigenic drivers is a topic of ongoing investigation. In this review, we examine the current methodologies underlying the identification of cancer‐associated lncRNAs and highlight important considerations for evaluating their biological significance as cancer drivers. |
| Databáze: | OpenAIRE |
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