TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy
| Autor: | Rajaraman Swaminathan, Mani Samson, Thangarajan Rajkumar, Urmila Mahji, Nirmala Karunakaran Nancy, Ranganathan Rama, V Sridevi |
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| Rok vydání: | 2007 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty India Single-nucleotide polymorphism Antineoplastic Agents Breast Neoplasms Biology Polymerase Chain Reaction Polymorphism Single Nucleotide GSTP1 Breast cancer Risk Factors Transforming Growth Factor beta Internal medicine medicine Odds Ratio SNP Humans Genetic Predisposition to Disease Genetic Testing Risk factor Mastectomy Glutathione Transferase Extracellular Matrix Proteins Cancer DNA Neoplasm medicine.disease Primary tumor Neoadjuvant Therapy Glutathione S-Transferase pi Chemotherapy Adjuvant Case-Control Studies Immunology Female Radiotherapy Adjuvant Breast disease Tumor Suppressor Protein p53 Polymorphism Restriction Fragment Length |
| Zdroj: | Breast cancer research and treatment. 112(1) |
| ISSN: | 0167-6806 |
| Popis: | The breast cancer incidence has been increasing in the south Indian women. A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Polymorphisms (SNP's) in GSTM1 (Present/Null); GSTP1 (Ile105Val), p53 (Arg72Pro), TGFbeta1 (Leu10Pro), c-erbB2 (Ile655Val), and GSTT1 (Null/Present) in breast cancer. In addition, the value of the SNP's in predicting primary tumor's pathologic response following neo-adjuvant chemo-radiotherapy was assessed. Genotyping was done using PCR (GSTM1, GSTT1), Taqman Allelic discrimination assay (GSTP1, c-erbB2) and PCR-CTPP (p53 and TGFbeta1). None of the gene SNP's studied were associated with a statistically significant increased risk for the breast cancer. However, combined analysis of the SNP's showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis. There was no statistically significant association for the GST family members with the breast cancer risk. TGFbeta1 (Pro/Pro) allele was found to predict complete pathologic response in the primary tumour following neo-adjuvant chemo-radiotherapy (OR=6.53 and 10.53 in Univariate and Multivariate analysis respectively) (P=0.004) and was independent of stage. This study suggests that SNP's can help predict breast cancer risk in south Indian women and that TGFbeta1 (Pro/Pro) allele is associated with a better pCR in the primary tumour. |
| Databáze: | OpenAIRE |
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