Some further properties of human pulmonary mast cells recovered by bronchoalveolar lavage and enzymic dispersion of lung tissue
| Autor: | K. Seager, K. B. P. Leung, B. N. Hudspith, K. C. Flint, Frederick L. Pearce, Hammond, J. Brostoff, N. M. Johnson |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Immunology Bronchi Cell Separation Basophil Toxicology Immunoglobulin E Histamine Release chemistry.chemical_compound medicine Humans Pharmacology (medical) Mast Cells Therapeutic Irrigation Lung Aged Pharmacology Leukotriene biology Leukotriene C4 medicine.diagnostic_test Prostaglandin D2 Prostaglandins D Osmolar Concentration respiratory system Middle Aged respiratory tract diseases Basophils Pulmonary Alveoli medicine.anatomical_structure Bronchoalveolar lavage chemistry biology.protein lipids (amino acids peptides and proteins) Female SRS-A Histamine |
| Zdroj: | Agents and actions. 20(3-4) |
| ISSN: | 0065-4299 |
| Popis: | The properties of human pulmonary mast cells obtained by bronchoalveolar lavage (BAL) and enzymic dispersion of lung tissue have been compared with those of basophil leucocytes. On challenge with anti-human IgE, the pulmonary cells released both histamine and the newly generated mediators prostaglandin D2 (PGD2) and leukotriene C4 (LTC4). In contrast, the blood leucocytes released histamine but very little leukotriene and no prostanoid. Interestingly, both basophil leucocytes and BAL cells released histamine spontaneously in a hyperosmolar environment whereas dispersed lung (DL) cells showed limited reactivity under these conditions. The possible clinical significance of these findings in human bronchial asthma is discussed. |
| Databáze: | OpenAIRE |
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