Hypothermic Effects of Neuropeptide FF Analogues in Mice
| Autor: | J M Zajac, C Desprat |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Narcotic Antagonists Clinical Biochemistry Hypothermia (+)-Naloxone Toxicology Biochemistry Body Temperature Mice Behavioral Neuroscience Internal medicine medicine Animals Neuropeptide FF Biological Psychiatry Pharmacology Chemistry Thermoregulation Endocrinology Opioid Mechanism of action Morphine Female medicine.symptom Oligopeptides Opioid antagonist medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 58:559-563 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(97)00249-9 |
| Popis: | The effects of neuropeptide FF (NPFF) and its analogues on mouse body temperature were examined. In a thermoneutral environment, administration of NPFF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2), 1DMe ([D.Tyr1, (N.Me)Phe3] NPFF), and 3D ([D.Tyr1, D.Leu2, D.Phe3] NPFF) in the third ventricle produced marked hypothermia. The effect of 1DMe was dose-dependent, and 45 nmol decreased body temperature by 5.6 degrees C. This effect was more pronounced when mice were placed at 4 degrees C. Hypothermia was not reversed by naloxone, an opioid antagonist, and was not modified by morphine. After 5 days of chronic treatment with 1DMe, mice did not became tolerant to the hypothermic effect. These results indicate that central NPFF receptors may control body temperature independently from opioid functions. |
| Databáze: | OpenAIRE |
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