Xmab21l3 mediates dorsoventral patterning in Xenopus laevis
| Autor: | Tomomi Haremaki, Daniel C. Weinstein, Sushma Teegala, Jyotsna Sridharan, Ye Jin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Mesoderm
Embryology Time Factors animal structures Transcription Genetic MAP Kinase Signaling System Xenopus Bone Morphogenetic Protein 2 Ectoderm SMAD Germ layer Xenopus Proteins Biology Article Xenopus laevis 03 medical and health sciences 0302 clinical medicine medicine Animals Gene family Promoter Regions Genetic Phylogeny Body Patterning 030304 developmental biology 0303 health sciences Gene Expression Regulation Developmental Embryo biology.organism_classification Molecular biology medicine.anatomical_structure Gene Knockdown Techniques embryonic structures Neural development 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Mechanisms of Development. 129(5-8):136-146 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/j.mod.2012.05.002 |
| Popis: | Specification of the dorsoventral (DV) axis is critical for the subsequent differentiation of regional fate in the primary germ layers of the vertebrate embryo. We have identified a novel factor that is essential for dorsal development in embryos of the frog Xenopus laevis. Misexpression of Xenopus mab21-like 3 (Xmab21l3) dorsalizes gastrula-stage mesoderm and neurula-stage ectoderm, while morpholino-mediated knockdown of Xmab21l3 inhibits dorsal differentiation of these embryonic germ layers. Xmab21l3 is a member of a chordate-specific subclass of a recently characterized gene family, all members of which contain a conserved, but as yet ill-defined, Mab21 domain. Our studies suggest that Xmab21l3 functions to repress ventralizing activity in the early vertebrate embryo, via regulation of BMP/Smad and Ras/ERK signaling. |
| Databáze: | OpenAIRE |
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