Prevalence of Non-alcoholic Steatohepatitis in Morbidly Obese Subjects Undergoing Gastric Bypass
| Autor: | Laurie Spaulding, Thomas Trainer, Dorota J Janiec |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Gastric Bypass Comorbidity Risk Assessment Severity of Illness Index digestive system Gastroenterology Sampling Studies Age Distribution Weight loss Internal medicine Hyperlipidemia Prevalence medicine Humans Prospective Studies Sex Distribution Prospective cohort study Nutrition and Dietetics medicine.diagnostic_test business.industry Incidence (epidemiology) Biopsy Needle nutritional and metabolic diseases Anastomosis Roux-en-Y medicine.disease Immunohistochemistry Obesity digestive system diseases Obesity Morbid Surgery Fatty Liver Liver biopsy Female Steatohepatitis Steatosis medicine.symptom business Follow-Up Studies |
| Zdroj: | Obesity Surgery. 13:347-349 |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1381/096089203765887633 |
| Popis: | Background: Obesity is the most common cause of non-alcoholic steatohepatitis (NASH). This is a prospective study to determine the incidence and severity of NASH in patients undergoing Roux-en-Y gastric bypass (RYGBP) for morbid obesity. We also examined the relationship between NASH and potential risk factors. Methods: In 48 consecutive patients at RYGBP, a core liver biopsy was obtained from the left lateral segment. A single liver pathologist reviewed the histology for steatosis, ballooning/disarray, necroinflammation, and fibrosis. Results: 84% of patients were female, and average BMI was 51. 18% had WHR >1. The following risk factors were present: DM 16%; hyperlipidemia 61%; HTN 47%; and abnormal LFTs 18%. 90% had abnormal liver histology, and 56% qualified for the diagnosis of NASH. Only DM and abnormal LFTs were found to be significantly related to NASH. Conclusions: NASH is a common co-morbidity of obesity and requires systemized grading and staging to develop accurate knowledge of the incidence, severity, natural history and impact of weight loss. |
| Databáze: | OpenAIRE |
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