Ocular Surface Residence Times of Artificial Tear Solutions
| Autor: | C G Wilson, G R Snibson, J M Tiffany, J L Greaves, Anthony J. Bron, N D W Soper |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_treatment
Sodium hyaluronate Biological Availability Keratoconjunctivitis Sicca Methylcellulose Residence time (fluid dynamics) Polyvinyl alcohol Cornea chemistry.chemical_compound Hypromellose Derivatives Gamma scintigraphy medicine Humans KERATOCONJUNCTIVITIS SICCA Hyaluronic Acid Radionuclide Imaging Chromatography Viscosity Chemistry Ophthalmology Artificial tears Polyvinyl Alcohol Technetium Tc 99m Pentetate Ophthalmic Solutions Ocular surface Half-Life |
| Zdroj: | Cornea. 11:288-293 |
| ISSN: | 0277-3740 |
| DOI: | 10.1097/00003226-199207000-00003 |
| Popis: | Solutions of hydroxypropylmethylcellulose (HPMC) and polyvinyl alcohol (PVA) are widely used as artificial tears. However, their usefulness is limited by the short duration of their effect. Dilute sodium hyaluronate (SH) solutions exhibit non-Newtonian rheology with high viscosities at low shear rates, which would be expected to enhance their ocular surface residence time. Using quantitative gamma scintigraphy, estimates of the ocular surface residence times of 0.3% HPMC, 1.4% PVA, and 0.2% SH were made in six patients with keratoconjunctivitis sicca. The sodium hyaluronate solution had a mean half-life on the ocular surface of 321 s, significantly longer than hydroxypropylmethylcellulose (44 s; p = 0.012) and polyvinyl alcohol (39 s; p = 0.013). |
| Databáze: | OpenAIRE |
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