Management of peri-anal giant condyloma acuminatum—A case report and literature review
| Autor: | Haytham El-Salhat, Mouied Alashari, Omar Bekdache, Suhail Al-Salam, Farouk Safi, Taha Mazen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy lcsh:Surgery Anal Canal diagnostic Malignancy Surgical Flaps Malignant transformation Colostomy Buschke and Loewenstein tumor medicine Carcinoma Humans development and therapy skin and connective tissue diseases Aged Aged 80 and over Anus Diseases Giant condyloma acuminatum medicine.diagnostic_test business.industry Benignity Rectum Multimodal therapy lcsh:RD1-811 Middle Aged Anus Neoplasms medicine.disease Dermatology Surgery Cell Transformation Neoplastic medicine.anatomical_structure Condylomata Acuminata Carcinoma Squamous Cell Female Laparoscopy business Penis |
| Zdroj: | Scipedia Open Access Scipedia SL Asian Journal of Surgery, Vol 36, Iss 1, Pp 43-52 (2013) |
| ISSN: | 1015-9584 |
| DOI: | 10.1016/j.asjsur.2012.06.013 |
| Popis: | SummaryGiant condyloma acuminatum (GCA), originally described by Buschke and Loewenstein in 1925 as a lesion of the penis, is more rarely seen in the anorectum and is characterized by clinical malignancy in the face of histologic benignity; however, malignant transformation to frankly invasive squamous-cell carcinoma has been described in about one-third of patients. In addition, malignant transformation has been reported in patients with "ordinary" condylomata acuminata. Human papillomavirus, known to cause condylomata acuminata, is also known to induce these tumors and was found in 96% of 63 cases reviewed in the last 10 years. These lesions have a propensity for recurrence and a likelihood of malignant transformation, and lead to significant mortality. Therefore, early and radical R0 excision, along with vigilant follow-up, provides the hope for cure. Conservative and/or multimodal therapy has been reported in a few cases, but its effect is not yet proved. The authors report one case of GCA; in addition, they reviewed the literature over the last 10 years and compared with previous reviews. |
| Databáze: | OpenAIRE |
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