Ischemic Stroke Due to Heparin-induced Thrombocytopenia during Severe COVID-19 Infection

Autor:	Yasutaka Murakami, Shuhei Okazaki, Makoto Yamamoto, Rei Sakurai, Jyunki Jinno, Tatsuhiko Ozono, Kensuke Ikenaka, Yasufumi Gon, Kenichi Todo, Tsutomu Sasaki, Haruhiko Hirata, Akinori Uchiyama, Hideki Mochizuki
Rok vydání:	2022
Předmět:	Heparin Internal Medicine Anticoagulants COVID-19 Humans Female Venous Thromboembolism General Medicine Middle Aged Thrombocytopenia Ischemic Stroke
Zdroj:	Internal Medicine. 61:2797-2801
ISSN:	1349-7235 0918-2918
Popis:	A 53-year-old woman with severe coronavirus disease 2019 (COVID-19) pneumonia was admitted and treated with intravenous unfractionated heparin for thromboprophylaxis under general anesthesia with mechanical ventilation. She developed right hemiparesis after hospitalization due to a large hemorrhagic infarction. Her platelet count decreased from 243,000/μL at administration to 121,000/μL. Anti-platelet factor 4-heparin antibody testing was positive according to a latex immunoturbidimetric assay. She was therefore diagnosed with heparin-induced thrombocytopenia. We immediately stopped the heparin and started argatroban; the platelet count recovered, and thrombosis did not relapse. Physicians should consider heparin-induced thrombocytopenia as a cause of ischemic stroke in patients with COVID-19 infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::735ce45c9b776059170dc089b7e31638 https://doi.org/10.2169/internalmedicine.9531-22 Zobrazit plný text záznamu