Pharmacokinetics of Aripiprazole, a New Antipsychotic, following Oral Dosing in Healthy Adult Japanese Volunteers: Influence of CYP2D6 Polymorphism
| Autor: | Junichi Azuma, Masanori Kubo, Hiromi Maune, Toshiko Koue, Tsuyoshi Fukuda |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
CYP2D6 medicine.medical_treatment Aripiprazole Administration Oral Pharmaceutical Science Quinolones Pharmacology Drug Administration Schedule Piperazines Asian People Japan Pharmacokinetics Reference Values Polymorphism (computer science) Oral administration Humans Medicine Pharmacology (medical) Antipsychotic Biotransformation Active metabolite Polymorphism Genetic business.industry Homozygote Half-life Phenotype Cytochrome P-450 CYP2D6 business Antipsychotic Agents Tablets medicine.drug |
| Zdroj: | Drug Metabolism and Pharmacokinetics. 22:358-366 |
| ISSN: | 1347-4367 |
| Popis: | We investigated the pharmacokinetics (PK) of aripiprazole, a newly developed antipsychotic, and its active metabolite in healthy Japanese, and the influence of CYP2D6 polymorphism on the PK of aripiprazole. Following a single oral 6 mg dose, the mean C(max), t(max), and t(1/2, z) (terminal phase half life) of aripiprazole were 31.0 ng/mL, 3.6 hr, and 61.0 hr, respectively. The t(1/2, z) in CYP2D6 IM subjects (75.2 hr) was significantly (p |
| Databáze: | OpenAIRE |
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