Oxidative phosphorylation and hepatic changes in relation to prolonged aldosterone administration
| Autor: | G. M. Goldberg, E. Bedrak, V. Samoiloff |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Oxidative phosphorylation Aspartate Aminotransferases Mitochondrion Oxidative Phosphorylation chemistry.chemical_compound Mice Endocrinology Internal medicine Medicine Animals Aldosterone Adenosine Triphosphatases biology business.industry Alanine Transaminase Mitochondria Alanine transaminase chemistry Liver biology.protein business |
| Zdroj: | The Journal of endocrinology. 37(2) |
| ISSN: | 0022-0795 |
| Popis: | SUMMARY Prolonged aldosterone administration to mice was investigated in relation to liver function. Daily injections of 2 μg. d-aldosterone monoacetate/g. body weight for 60 days adversely affected oxidative phosphorylation of liver mitochondria. The value for the P:O ratio of controls, 3·21, dropped to 2·01, 2·86, 2·45 and 2·79 for mice treated with aldosterone for 20, 30, 50 and 60 days, respectively. The impaired oxidative phosphorylation was neither accompanied by an increase in adenosine triphosphatase activity of liver mitochondria nor by a change in plasma transaminases. Corresponding morphological changes were observed in liver parenchyma starting with hydropic degenerations in early lesions, and single cell necrosis accompanied by mitotic activity (regeneration) in advanced lesions. It seems therefore that hyperaldosteronism might be noxious to liver parenchyma and hepatic function. |
| Databáze: | OpenAIRE |
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