Protein Binding: A Fuzzy Concept

Autor:	Mike P. Williamson
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	affinity intrinsically disordered protein avidity effective concentration facilitated dissociation allovalency fuzzy binding protein-protein interaction Space and Planetary Science Paleontology General Biochemistry Genetics and Molecular Biology Ecology Evolution Behavior and Systematics
Zdroj:	Life; Volume 13; Issue 4; Pages: 855
ISSN:	2075-1729
DOI:	10.3390/life13040855
Popis:	Our understanding of protein binding interactions has matured significantly over the last few years, largely as a result of trying to make sense of the binding interactions of intrinsically disordered proteins. Here, we bring together some disparate ideas that have largely developed independently, and show that they can be linked into a coherent picture that provides insight into quantitative aspects of protein interactions, in particular that transient protein interactions are often optimised for speed, rather than tight binding.
Databáze:	OpenAIRE
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