Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath
| Autor: | Hossam Haick, Qianyu Zhang, Yong Wang, Wenyu Li, Qiujun Zhang, Zhengzheng Liu, Dandan Hu, Wei Jin, Wenjuan Li, Shoubing Zhou, Hu Liu, Lin Wang, Jinquan Wang, Jiong Wang, Zhihong Zhang, Lin Lin, Yoav Y. Broza, Wei Liu, Shuyu Gui, Sihan Wu, Yueyin Pan, Benjie Shan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty China Coronavirus disease 2019 (COVID-19) diagnosis Pneumonia Viral Respiratory System General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences Sensitivity and Specificity Article Betacoronavirus Sensor array Asian People sensor Active disease Medicine Humans General Materials Science Epidemic control Pandemics breath business.industry SARS-CoV-2 General Engineering COVID-19 Middle Aged 021001 nanoscience & nanotechnology Linear discriminant analysis 0104 chemical sciences Data Accuracy Nanostructures Breath Tests Test set New disease Emergency medicine Biomarker (medicine) biomarker Female 0210 nano-technology business Coronavirus Infections Biomarkers |
| Zdroj: | ACS Nano |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | This article reports on a noninvasive approach in detecting and following-up individuals who are at-risk or have an existing COVID-19 infection, with a potential ability to serve as an epidemic control tool. The proposed method uses a developed breath device composed of a nanomaterial-based hybrid sensor array with multiplexed detection capabilities that can detect disease-specific biomarkers from exhaled breath, thus enabling rapid and accurate diagnosis. An exploratory clinical study with this approach was examined in Wuhan, China, during March 2020. The study cohort included 49 confirmed COVID-19 patients, 58 healthy controls, and 33 non-COVID lung infection controls. When applicable, positive COVID-19 patients were sampled twice: during the active disease and after recovery. Discriminant analysis of the obtained signals from the nanomaterial-based sensors achieved very good test discriminations between the different groups. The training and test set data exhibited respectively 94% and 76% accuracy in differentiating patients from controls as well as 90% and 95% accuracy in differentiating between patients with COVID-19 and patients with other lung infections. While further validation studies are needed, the results may serve as a base for technology that would lead to a reduction in the number of unneeded confirmatory tests and lower the burden on hospitals, while allowing individuals a screening solution that can be performed in PoC facilities. The proposed method can be considered as a platform that could be applied for any other disease infection with proper modifications to the artificial intelligence and would therefore be available to serve as a diagnostic tool in case of a new disease outbreak. |
| Databáze: | OpenAIRE |
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