Chemical and Biological Investigation of the Fungus Pulveroboletus ravenelii

Autor:	Mark T. Hamann, Samir A. Ross, Frank R. Fronczek, Muriel Cuendet, J. M. Pezzuto, Rajendra G. Mehta, Christine J. G. Duncan
Rok vydání:	2002
Předmět:	Models Molecular Molecular Conformation Pharmaceutical Science Pharmacognosy Crystallography X-Ray Organ culture Article Analytical Chemistry Inhibitory Concentration 50 Mice chemistry.chemical_compound Mississippi Organ Culture Techniques Drug Discovery Animals Anticarcinogenic Agents Cyclooxygenase Inhibitors Furans Nuclear Magnetic Resonance Biomolecular Phenylacetates Antibacterial agent Pharmacology chemistry.chemical_classification Mice Inbred BALB C Molecular Structure Vulpinic acid Organic Chemistry Mammary Neoplasms Experimental Stereoisomerism Biological activity Antimicrobial In vitro Enzyme Complementary and alternative medicine Biochemistry chemistry Molecular Medicine Female Agaricales
Zdroj:	Journal of Natural Products. 66:103-107
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np0203990
Popis:	Two new compounds, pulveraven A (1) and pulveraven B (2), as well as vulpinic acid (3) and its previously unreported polymorph were isolated from the fruiting body of Pulveroboletus ravenelii. The structures were determined using a combination of NMR, MS, IR, optical rotation, molecular modeling, and X-ray analysis. The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7356e1da8a34252790ea465d5bd7ad02 https://doi.org/10.1021/np0203990 Zobrazit plný text záznamu