Vascular endothelial growth factor in porcine coronary arteries following balloon angioplasty
| Autor: | Slee A, Orsini Ja, Merrill Jj, Hausner Ea, Perkowski Sz, Modzelewski Tc, Foster Ll |
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| Rok vydání: | 1999 |
| Předmět: |
Neointima
Vascular Endothelial Growth Factor A medicine.medical_specialty Intimal hyperplasia Arteriosclerosis Swine medicine.medical_treatment Saturated fat Neovascularization Physiologic Endothelial Growth Factors Cholesterol Dietary chemistry.chemical_compound Angioplasty Adventitia Internal medicine Proliferating Cell Nuclear Antigen medicine Animals Angioplasty Balloon Coronary Lymphokines Wound Healing business.industry Vascular Endothelial Growth Factors medicine.disease Coronary Vessels Dietary Fats Vascular endothelial growth factor Coronary arteries medicine.anatomical_structure Cholesterol chemistry cardiovascular system Cardiology Surgery business Tunica Intima Tunica Media Artery |
| Zdroj: | Journal of investigative surgery : the official journal of the Academy of Surgical Research. 12(1) |
| ISSN: | 0894-1939 |
| Popis: | The present study was a preliminary inquiry into the presence of vascular endothelial growth factor (VEGF) in a model of coronary artery response to injury. We examined domestic pigs who had received a diet enriched in saturated fat and cholesterol and undergone balloon angioplasty of one or more coronary arteries. Immunohistochemical analysis of the coronary arteries 2 months after injury revealed the presence of VEGF distributed throughout the media and neointima of the angioplasty lesions and in association with blood vessels in the adventitia and those vessels growing into the base of the neointima. VEGF was also detected in areas of dietary-induced intimal proliferation. This study provided the first immunochemical demonstration of VEGF occuring naturally in a pig model of coronary response to injury. |
| Databáze: | OpenAIRE |
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