Resting Energy Expenditure Is Elevated in Asthma
| Autor: | Suzy A.A. Comhair, Kristin K. Hoddy, Sarah Micklewright, Anny Mulya, Emily Pennington, Steven B. Heymsfield, Peng Zhang, Stephanie McCarroll, Laura Peterson, Serpil C. Erzurum, Jacob T. Mey, John P. Kirwan, Michelle Koo, Catherine M. Champagne, Brittany Matuska, Jacqueline Sharp, Patrick Wyszynski, Mark A. Aronica |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Spirometry medicine.medical_specialty Pathophysiology of asthma lcsh:TX341-641 airway inflammation Article Body Mass Index 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine respiratory function Internal medicine medicine Humans Respiratory function Resting energy expenditure Asthma body composition Nutrition and Dietetics medicine.diagnostic_test business.industry Complete blood count Calorimetry Indirect medicine.disease resting energy expenditure respiratory tract diseases Cross-Sectional Studies nutrition 030104 developmental biology Endocrinology 030228 respiratory system Exhaled nitric oxide Female Basal Metabolism business lcsh:Nutrition. Foods and food supply Body mass index Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 1065, p 1065 (2021) Volume 13 Issue 4 |
| ISSN: | 2072-6643 |
| Popis: | Background: Asthma physiology affects respiratory function and inflammation, factors that may contribute to elevated resting energy expenditure (REE) and altered body composition. Objective: We hypothesized that asthma would present with elevated REE compared to weight-matched healthy controls. Methods: Adults with asthma (n = 41) and healthy controls (n = 20) underwent indirect calorimetry to measure REE, dual-energy X-ray absorptiometry (DEXA) to measure body composition, and 3-day diet records. Clinical assessments included spirometry, fractional exhaled nitric oxide (FENO), and a complete blood count. Results: Asthmatics had greater REE than controls amounting to an increase of ~100 kcals/day, even though body mass index (BMI) and body composition were similar between groups. Inclusion of asthma status and FENO in validated REE prediction equations led to improved estimates. Further, asthmatics had higher white blood cell (control vs. asthma (mean ± SD): 4.7 ± 1.1 vs. 5.9 ± 1.6, p < 0.01) and neutrophil (2.8 ± 0.9 vs. 3.6 ± 1.4, p = 0.02) counts that correlated with REE (both p < 0.01). Interestingly, despite higher REE, asthmatics reported consuming fewer calories (25.1 ± 7.5 vs. 20.3 ± 6.0 kcals/kg/day, p < 0.01) and carbohydrates than controls. Conclusion: REE is elevated in adults with mild asthma, suggesting there is an association between REE and the pathophysiology of asthma. |
| Databáze: | OpenAIRE |
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