Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis1
| Autor: | Whitfield, Marjorie, Ouvrier, Aurélia, Cadet, Rémi, Damon-Soubeyrand, Christelle, Guiton, Rachel, Janny, Laurent, Kocer, Ayhan, Marceau, Geoffroy, Pons-Rejraji, Hanae, Trousson, Amalia, Drevet, Joël R, Saez, Fabrice, Drevet, Joël R. |
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| Přispěvatelé: | Clermont Université, Génétique, Reproduction et Développement - Clermont Auvergne (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), CHU Clermont-Ferrand, Régulation de la transcription et maladies génétiques (RTMG), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Génétique, Reproduction et Développement (GReD), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Gene isoform medicine.medical_specialty Transgene [SDV]Life Sciences [q-bio] Biology cholesterol homeostasis lipids 03 medical and health sciences 0302 clinical medicine Capacitation spermatozoa Internal medicine medicine Liver X receptor 030219 obstetrics & reproductive medicine Spermatozoon urogenital system Lipid metabolism Cell Biology General Medicine Epididymis Sperm 030104 developmental biology medicine.anatomical_structure Endocrinology Reproductive Medicine inflammation lipids (amino acids peptides and proteins) LXR epididymis |
| Zdroj: | Biology of Reproduction Biology of Reproduction, Society for the Study of Reproduction, 2016, 94 (3), pp.55. ⟨10.1095/biolreprod.115.133538⟩ Biology of Reproduction, 2016, 94 (3), pp.55. ⟨10.1095/biolreprod.115.133538⟩ |
| ISSN: | 0006-3363 1529-7268 |
| DOI: | 10.1095/biolreprod.115.133538⟩ |
| Popis: | International audience; After its production in the testis, a spermatozoon has to undergo posttesticular maturation steps to become fully motile and fertile. The first step is epididymal maturation, during which immature spermatozoa are transformed into biochemically mature cells ready to proceed to the next step, capacitation, a physiological process occurring in the female genital tract. The biochemical transformations include modification of sperm lipid composition during epididymal transit, with significant changes in fatty acids, phospholipids, and sterols between the caput and the cauda epididymal spermatozoa. Although quantitative aspects of these changes are well documented for several mammalian species, molecular mechanisms governing these steps are poorly understood. Transgenic male mice invalidated for the two liver X receptors (LXRalpha and LXRbeta, nuclear oxysterol receptors regulating cholesterol and lipid metabolism) become sterile when aging, showing an epididymal phenotype. We used single-knockout-model mice to characterize the role of each LXR isoform during sperm maturation in the epididymis. We show here that although a certain redundancy exists in the functions of the two LXR isoforms, some physiological processes are more under the influence of only one of them. In both cases, aging males showed slight subfertility, associated with dyslipidemia, emphasizing the importance of lipid metabolism in relation with male fertility. |
| Databáze: | OpenAIRE |
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