Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity

Autor: Hansoo Park, Sungsoon Fang, Mongjoo Jang, Jeong Hyeon Park, Youngmin Yoon, Gihyeon Kim, Myung-Giun Noh
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Limosilactobacillus fermentum
Clinical Biochemistry
Adipose tissue
White adipose tissue
Gut flora
Biochemistry
Oxidative Phosphorylation
chemistry.chemical_compound
Mice
0302 clinical medicine
Lactobacillus
Adipocyte
biology
food and beverages
Metabolic syndrome
Adipose Tissue
Liver
Molecular Medicine
Medicine
Disease Susceptibility
Signal Transduction
medicine.medical_specialty
Lactobacillus fermentum
030209 endocrinology & metabolism
Oxidative phosphorylation
QD415-436
Diet
High-Fat
digestive system
Article
03 medical and health sciences
Internal medicine
3T3-L1 Cells
Metabolome
medicine
Animals
Metabolomics
Obesity
Molecular Biology
Gene Expression Profiling
Probiotics
Body Weight
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
Endocrinology
chemistry
bacteria
Gene expression
Biomarkers
Zdroj: Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1574-1586 (2020)
Experimental & Molecular Medicine
ISSN: 2092-6413
1226-3613
Popis: The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.
Obesity: Microbial defenders of metabolic health The presence of particular bacterial species in the healthy gut microbiome can reduce the risk of obesity by modulating metabolic activity in host tissues. Several studies have suggested that intestinal microbes from the genus Lactobacillus can counteract weight gain and fat accumulation in humans and mice. Researchers in South Korea led by Sungsoon Fang at Yonsei University College of Medicine, Seoul, and Hansoo Park at the Gwangju Institute of Science and Technology have now examined the physiological effects of one such species, Lactobacillus fermentum LM1016, in mice. The researchers showed that this bacterium could reduce the risk of diet-induced obesity and fat accumulation in the liver, and identified relevant shifts in the activity of key metabolic and inflammatory pathways. If these findings are confirmed in humans, this bacterial strain could serve as an effective probiotic.
Databáze: OpenAIRE
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