Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity
Autor: | Hansoo Park, Sungsoon Fang, Mongjoo Jang, Jeong Hyeon Park, Youngmin Yoon, Gihyeon Kim, Myung-Giun Noh |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Limosilactobacillus fermentum Clinical Biochemistry Adipose tissue White adipose tissue Gut flora Biochemistry Oxidative Phosphorylation chemistry.chemical_compound Mice 0302 clinical medicine Lactobacillus Adipocyte biology food and beverages Metabolic syndrome Adipose Tissue Liver Molecular Medicine Medicine Disease Susceptibility Signal Transduction medicine.medical_specialty Lactobacillus fermentum 030209 endocrinology & metabolism Oxidative phosphorylation QD415-436 Diet High-Fat digestive system Article 03 medical and health sciences Internal medicine 3T3-L1 Cells Metabolome medicine Animals Metabolomics Obesity Molecular Biology Gene Expression Profiling Probiotics Body Weight biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Endocrinology chemistry bacteria Gene expression Biomarkers |
Zdroj: | Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1574-1586 (2020) Experimental & Molecular Medicine |
ISSN: | 2092-6413 1226-3613 |
Popis: | The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity. Obesity: Microbial defenders of metabolic health The presence of particular bacterial species in the healthy gut microbiome can reduce the risk of obesity by modulating metabolic activity in host tissues. Several studies have suggested that intestinal microbes from the genus Lactobacillus can counteract weight gain and fat accumulation in humans and mice. Researchers in South Korea led by Sungsoon Fang at Yonsei University College of Medicine, Seoul, and Hansoo Park at the Gwangju Institute of Science and Technology have now examined the physiological effects of one such species, Lactobacillus fermentum LM1016, in mice. The researchers showed that this bacterium could reduce the risk of diet-induced obesity and fat accumulation in the liver, and identified relevant shifts in the activity of key metabolic and inflammatory pathways. If these findings are confirmed in humans, this bacterial strain could serve as an effective probiotic. |
Databáze: | OpenAIRE |
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