Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases
| Autor: | Mingfei Chen, Xuejun Zhang, Shanshan Ma, Yonghu Sun, Dianchang Liu, Furen Zhang, Xi'an Fu, Guiye Niu, Na Wang, Jinghui Li, Astrid Irwanto, Yan Zhou, Chuan Wang, Jiabao You, Hongqing Tian, Jianjun Liu, Qing Yang, Shumin Chen, Benqing Shi, Yi Li, Gongqi Yu, Lin Zhang, Chunying Yuan, Hui Qi Low, Tongsheng Chu, Nan Lu, Fangfang Bao, H. Liu, Hong Liu, Jian Liu, Xiulu Yu, Yongxiang Yu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Biology Polymorphism Single Nucleotide Inflammatory bowel disease Pathogenesis Interferon-gamma 03 medical and health sciences 0302 clinical medicine Leprosy Report otorhinolaryngologic diseases Genetics medicine Genetic predisposition Humans Genetics(clinical) Genetic Predisposition to Disease Genetics (clinical) Aged 030304 developmental biology Genetic association Aged 80 and over 0303 health sciences Interleukin-12 Subunit p40 Case-control study IL18R1 Odds ratio Middle Aged Inflammatory Bowel Diseases medicine.disease 3. Good health Case-Control Studies 030220 oncology & carcinogenesis Immunology Female Interleukin-18 Receptor alpha Subunit |
| Zdroj: | The American Journal of Human Genetics. 91:935-941 |
| ISSN: | 0002-9297 |
| DOI: | 10.1016/j.ajhg.2012.09.010 |
| Popis: | Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|