Antioxidant Barrier, Redox Status, and Oxidative Damage to Biomolecules in Patients with Colorectal Cancer. Can Malondialdehyde and Catalase Be Markers of Colorectal Cancer Advancement?
Autor: | Wioletta Romaniuk, Katarzyna Guzińska-Ustymowicz, Adam Roman Markowski, Konrad Zaręba, Mateusz Maciejczyk, Justyna Zińczuk, Joanna Matowicka-Karna, Anna Pryczynicz, Bogusław Kędra, Anna Zalewska |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Antioxidant medicine.medical_treatment Glutathione reductase lcsh:QR1-502 colorectal cancer medicine.disease_cause Biochemistry Article lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Malondialdehyde Internal medicine Biomarkers Tumor medicine Humans oxidative stress Molecular Biology chemistry.chemical_classification redox biomarkers biology Chemistry Glutathione peroxidase Glutathione Catalase 030104 developmental biology Endocrinology antioxidants ROC Curve Advanced oxidation protein products 030220 oncology & carcinogenesis biology.protein Female Colorectal Neoplasms Oxidation-Reduction Oxidative stress |
Zdroj: | Biomolecules, Vol 9, Iss 10, p 637 (2019) Biomolecules Volume 9 Issue 10 |
Popis: | This study is the first to assess the diagnostic utility of redox biomarkers in patients with colorectal cancer (CRC). Antioxidant barrier (Cu,Zn-superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), uric acid (UA), reduced glutathione (GSH)), redox status (total antioxidant (TAC)/oxidant status (TOS), ferric reducing ability (FRAP)), and oxidative damage products (advanced glycation end products (AGE), advanced oxidation protein products (AOPP), malondialdehyde (MDA)) were measured in serum/plasma samples of 50 CRC patients. The activity of SOD was significantly higher whereas the activity of CAT, GPx and GR was considerably lower in CRC patients compared to the control group (p < 0.0001). Levels of UA, TOS, and OSI and concentrations of AGE, AOPP, and MDA were significantly higher, and the levels of GSH, TAC, and FRAP were considerably lower in CRC patients compared to the healthy controls (p < 0.0001). AUC for CAT with respect to presence of lymph node metastasis was 0.7450 (p = 0.0036), whereas AUC for MDA according to the depth of tumour invasion was 0.7457 (p = 0.0118). CRC is associated with enzymatic/non-enzymatic redox imbalance as well as increased oxidative damage to proteins and lipids. Redox biomarkers can be potential diagnostic indicators of CRC advancement. |
Databáze: | OpenAIRE |
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