The neuropeptide galanin adopts an irregular secondary structure

Autor:	Rachel E. Wilkinson, Katelyn N. Kraichely, Cecilia M. Hendy, Lauren E. Buchanan, Stuart Parnham, Michael W. Giuliano
Rok vydání:	2022
Předmět:	Magnetic Resonance Spectroscopy Peptide Hormones Biophysics Humans Galanin Amino Acid Sequence Cell Biology Molecular Biology Biochemistry Protein Structure Secondary
Zdroj:	Biochemical and Biophysical Research Communications. 626:121-128
ISSN:	0006-291X
DOI:	10.1016/j.bbrc.2022.08.032
Popis:	Human galanin is a 30-residue neuropeptide targeted for development of analgesics, antidepressants, and anticonvulsants. While previous work from our group and others has already produced significant insights into galanin's N-terminal region, no extant structures of galanin in databases include its full-length sequence and the function of its C-terminus remains ambiguous. We report the NMR solution structure of full-length human galanin C-terminal amide, determined from 2D
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7352d6cf5dfc974381dbd3a1a9f22f26 https://doi.org/10.1016/j.bbrc.2022.08.032 Zobrazit plný text záznamu Full Text from ScienceDirect