The Effectiveness of Potential Probiotics Lactobacillus rhamnosus Vahe and Lactobacillus delbrueckii IAHAHI in Irradiated Rats Depends on the Nutritional Stage of the Host
| Autor: | Marine H. Balayan, Anahit M. Manvelyan, Gavin McCabe, Vardan V. Tsaturyan, Andrey V. Karlyshev, Richard Weeks, Michael L. Chikindas, Vyacheslav G. Melnikov, Astghik Z. Pepoyan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male celtic Cultured Milk Products Microorganism Riboflavin 030106 microbiology Biotin Nutritional Status alliedhealth Biology Gut flora Radiation Dosage Microbiology Radiation Tolerance law.invention 03 medical and health sciences Probiotic Leukocyte Count Folic Acid Lactobacillus rhamnosus law In vivo Lactobacillus Animals Humans Rats Wistar Radiation Injuries Radiometry Molecular Biology Lactobacillus delbrueckii Host (biology) Lacticaseibacillus rhamnosus Probiotics X-Rays food and beverages biology.organism_classification Survival Analysis infection Vitamin B 6 Gastrointestinal Microbiome Rats 030104 developmental biology Molecular Medicine epidemiology Fermentation biological Whole-Body Irradiation |
| Zdroj: | Probiotics and antimicrobial proteins. 12(4) |
| ISSN: | 1867-1314 1867-1306 |
| Popis: | Several species of eukaryotic organisms living in the high mountain areas of Armenia with naturally occurring levels of radiation have high adaptive responses to radiation. We speculate on the role of the gastrointestinal microbiota in this protection against radiation. Therefore, seventeen microorganisms with high antagonistic activities against several multi-drug-resistant pathogens were isolated from the human and animal gut microbiota, as well as from traditional Armenian fermented products. These strains were tested in vivo on Wistar rats to determine their ability to protect the eukaryotic host against radiation damages. The efficiency of the probiotics' application and the dependence on pre- and post-radiation nutrition of rats were described. The effects of Lactobacillus rhamnosus Vahe, isolated from a healthy breastfed infant, and Lactobacillus delbrueckii IAHAHI, isolated from the fermented dairy product matsuni, on the survival of irradiated rats, and their blood leucocyte and glucose levels, were considered to be the most promising, based on this study's results. |
| Databáze: | OpenAIRE |
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