Relationship between sleep disturbances, lipid profile and insulin sensitivity in type 1 diabetic patients: a cross-sectional study
| Autor: | Bruna Landeiro Tavares, Ana Carolina Musser Tavares de Mattos, Vitória Oliveira Fiorini, Yasmin Sab, Yuri Sofiati Campos, Rubens Antunes da Cruz Filho, Luis Guillermo Coca Velarde, Giovanna Aparecida Balarini Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology Pittsburgh Sleep Quality Index 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Surveys and Questionnaires insulin resistance medicine Sleep apnea obstructive Outpatient clinic Humans dyslipidemias Type 1 diabetes business.industry Epworth Sleepiness Scale medicine.disease RC648-665 Lipids extrinsic sleep disorder Obstructive sleep apnea Sleep deprivation Cross-Sectional Studies diabetes mellitus type 1 030220 oncology & carcinogenesis Medicine Female Metabolic syndrome medicine.symptom business |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 64, Iss 4, Pp 412-417 (2020) Archives of Endocrinology and Metabolism, Volume: 64, Issue: 4, Pages: 412-417, Published: 06 APR 2020 Archives of Endocrinology and Metabolism v.64 n.4 2020 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Issue: ahead, Published: 06 APR 2020 |
| ISSN: | 2359-4292 |
| Popis: | Objective The consequences of sleep deprivation in type 1 diabetes (T1D) patients are poorly understood. Our aim was to determine how sleep disorders influence lipid profile and insulin sensitivity in T1D patients. Materials and methods This was a cross-sectional study at a public university hospital. Demographic information and medical histories were obtained during regular scheduled visit of T1D patients to the outpatient clinic. Insulin sensitivity was obtained using the estimated glucose disposal rate (eGDR) formula. Sleep quality was assessed using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Berlin Questionnaire. Results The adult participants (n = 66, 62% women) had a median age of 28.0 years (interquartile range 21.8-33.0). Six patients (9%) had metabolic syndrome according to the International Diabetes Federation criteria. Thirty patients (46%) were considered poor sleepers according to the Pittsburgh Sleep Quality Index. The LDL-c and total cholesterol levels of poor sleepers were higher than those of good sleepers (103 v. 81; p = 0.003 and 178.0 v. 159.5 mg/dL; p = 0.009, respectively). Three patients (4%) were at high risk of obstructive sleep apnea syndrome (OSAS) according to the Berlin Questionnaire. The eGDR was lower in the group of patients with high probability of having OSAS (6.0 v. 9.1 mg.kg-1.min-1;p = .03). Conclusions Poor subjective quality of sleep and higher risk of OSAS were correlated with a worsened lipid profile and decreased insulin sensitivity, respectively. Therefore, T1D patients with sleep disturbances might have an increased cardiovascular risk in the future. |
| Databáze: | OpenAIRE |
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