Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission
| Autor: | Georgia C. Atella, Mário A.C. Silva-Neto, Alan B. Carneiro, Lívia Silva-Cardoso |
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| Rok vydání: | 2011 |
| Předmět: |
Chagas disease
education.field_of_study biology Population Chemotaxis Review Article biology.organism_classification medicine.disease lcsh:Infectious and parasitic diseases Cell biology chemistry.chemical_compound Infectious Diseases Immune system Lysophosphatidylcholine chemistry Immunology parasitic diseases medicine lcsh:RC109-216 Parasitology Rhodnius prolixus Trypanosoma cruzi education Triatominae |
| Zdroj: | Journal of Parasitology Research Journal of Parasitology Research, Vol 2012 (2012) |
| ISSN: | 2090-0031 |
| Popis: | Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organismRhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator ofTrypanosoma cruzitransmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by liveT. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease. |
| Databáze: | OpenAIRE |
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