Transiently positive anticardiolipin antibodies and risk of thrombosis in patients with systemic lupus erythematosus
Autor: | Guillermo Ruiz-Irastorza, Jose Gabriel Erdozain, Irama Villar, Ciriaco Aguirre, Maider Garmendia, Agustin Martinez-Berriotxoa, Maria-Victoria Egurbide |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male Risk medicine.medical_specialty Adolescent 030204 cardiovascular system & hematology Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic In patient Prospective Studies Child Aged 030203 arthritis & rheumatology Lupus anticoagulant biology business.industry Thrombosis Middle Aged medicine.disease INCEPTION COHORT Titer Antibodies Anticardiolipin Lupus Coagulation Inhibitor Immunology biology.protein Antibodies Antiphospholipid Anticardiolipin antibodies Female Antibody business |
Zdroj: | Lupus. 16(10) |
ISSN: | 0961-2033 |
Popis: | Fluctuations in the titers of anticardiolipin antibodies (aCL) have been reported in systemic lupus erythematosus (SLE) patients, but their relation with thrombosis is not completely understood. Prospective inception cohort of 237 patients with SLE (American College of Rheumatology criteria). Positivity for antiphospholipid antibodies (aPL) was defined according to Sapporo criteria. aCL was defined as persistently positive when more than two-thirds of the determinations were positive during follow-up. Patients were classified into four groups: A [positive lupus anticoagulant (LA)], B (negative LA and persistently positive aCL), C (negative LA and transiently positive aCL) and D (negative LA and aCL). Of these 237 patients, 211 (89%) patients were women. Median age at diagnosis and follow-up were 32 (2—78) and 10 (1—31) years, respectively; 33 (13.9%), 23 (9.7%), 42 (17.7%) and 139 (58.6%) patients were classified in groups A, B, C and D, respectively. Thirty (12.6%) and 23 (9.7%) patients suffered arterial and venous thrombotic events, respectively. Adjusted risk for arterial thrombosis was increased in groups A [odds ratio (OR) 15.69, 95% confidential interval (CI) 4.79—51.42, P < 0.001] and B (OR 7.63, 95% CI 2.00—29.08, P = 0.003), but not in group C when compared with group D. Adjusted risk of venous thrombosis was increased in group A (OR 4.24, 95% CI 1.36—13.20, P = 0.013), but not in groups B or C when compared with group D. Risk of thrombosis is not increased in SLE patients with negative LA and transiently positive aCL, even fulfilling Sapporo laboratory criteria, when compared with aPL-negative SLE patients. Lupus (2007) 16, 810—816. |
Databáze: | OpenAIRE |
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