Association study of IL10 gene polymorphisms (rs1800872 and rs1800896) with cervical cancer in the Bangladeshi women
| Autor: | Anamika Datta, Mohammad Sarowar Uddin, Sarah Jafrin, Shamsun Nahar, Shalahuddin Millat, Abdul Aziz, Fatema Tuz Zahora, Mahmuda Ferdous, Shahid Sarwar, Abdul Barek, Mohammad Safiqul Islam |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Linkage disequilibrium medicine.medical_specialty Genotype Immunology Uterine Cervical Neoplasms Gastroenterology Polymorphism Single Nucleotide 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine Databases Genetic medicine Immunology and Allergy Humans Genetic Predisposition to Disease Allele Genotyping Alleles Genetic Association Studies Pharmacology Cervical cancer Bangladesh business.industry Haplotype Middle Aged medicine.disease Interleukin-10 Interleukin 10 030104 developmental biology Bonferroni correction Haplotypes 030220 oncology & carcinogenesis Case-Control Studies symbols Carcinoma Squamous Cell Female business |
| Zdroj: | International immunopharmacology. 89 |
| ISSN: | 1878-1705 |
| Popis: | OBJECTIVE Cervical cancer is one of the most destructive diseases among females worldwide, especially in developing countries. Interleukin-10 (IL10) is a multifunctional cytokine, and polymorphisms in the IL10 gene have been identified in multiple malignancies. However, no prior studies were conducted to determine the association of IL10 polymorphisms (rs1800872 and rs1800896) with cervical cancer patients in Bangladesh. METHODS This case-control study was carried out on 240 cervical cancer patients and 204 healthy volunteers. Genotyping was performed using the tetra-primer amplification refractory mutation system polymerase chain reaction (ARMS-PCR). RESULTS In the case of rs1800872, CA and AA genotypes significantly increased the risk of cervical cancer (OR = 1.59, 95% CI = 1.01-2.49, p = 0.043; OR = 2.75, 95% CI = 1.53-4.93, p = 0.0007, respectively) but the significance did not exist for CA genotype after Bonferroni correction (p |
| Databáze: | OpenAIRE |
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