Dietary protein restriction and glomerular permselectivity in nephrotoxic serum nephritis
| Autor: | Robert G. Schacht, Arthur Kozin, Robert Gayner, David S. Baldwin, Joel Neugarten |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Kidney Glomerulus Hemodynamics Renal function Permeability Internal medicine medicine Animals Protein restriction Normal protein Kidney Nephritis Proteinuria urogenital system Chemistry Dextrans Rats Inbred Strains Glomerulonephritis medicine.disease Nephrotoxic serum nephritis Rats medicine.anatomical_structure Endocrinology Nephrology Dietary Proteins medicine.symptom |
| Zdroj: | Kidney International. 40(1):57-61 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1991.179 |
| Popis: | Dietary protein restriction and glomerular permselectivity in nephrotoxic serum nephritis. We have previously demonstrated that long-term dietary protein restriction ameliorates proteinuria and limits glomerular structural injury in rats with nephrotoxic serum nephritis. In the present study, we examined the influence of short-term dietary protein restriction on glomerular permselectivity. As compared to nephritic rats maintained on a normal protein diet, whole kidney and single nephron hemodynamics were lower in nephritic rats subjected to dietary protein restriction of three days duration (glomerular filtration rate: 0.79 ± 0.10 vs. 1.46 ± 0.11 ml/min, P < 0.003; renal plasma flow rate: 2.50 ± 0.34 vs. 3.96 ± 0.38 ml/min, P < 0.02; glomerular capillary pressure: 44 ± 1 vs. 53 ± 1mm Hg, P < 0.002; proteinuria: 77 ± 15 vs. 224 ± 14 mg/24 hr, P < 0.01). This was associated with a rise in afferent resistance, from 2.99 ± 0.77 to 5.45 ± 0.94 dyn · sec · cm-5, NS. In nephritic rats maintained on 24% protein, fractional clearances were elevated above control values for neutral dextrans with molecular radii exceeding 50 Å but were depressed for those with molecular radii below 30 Å (P < 0.05). Dietary protein restriction elevated the fractional clearances of dextrans with radii 50 Å (P < 0.05). The proportion of glomerular filtrate permeating the shunt pathway was elevated above control values in nephritic rats on the 24% protein diet but declined in those fed the low protein diet (NSN-24%: 0.86%; NSN-6%: 0.31% control: 0.19%). In conclusion, renal hemodynamics are impaired, proteinuria is reduced and glomerular size-selective barrier dysfunction is ameliorated by short-term dietary protein restriction in nephrotoxic serum nephritis. The reduction in proteinuria is mediated both by a decline in glomerular filtration rate and by improved glomerular size permselectivity due to reduced utilization of the shunt pathway. |
| Databáze: | OpenAIRE |
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