Translation attenuation regulation of chloramphenicol resistance in bacteria — a review
| Autor: | Paul S. Lovett |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Chloramphenicol O-Acetyltransferase
Genetics Peptidyl transferase Models Genetic biology Translational termination Chloramphenicol Resistance Translation (biology) Gene Expression Regulation Bacterial General Medicine Gram-Positive Bacteria Ribosome RNA Ribosomal 23S Internal ribosome entry site Protein Biosynthesis Gram-Negative Bacteria Peptidyl Transferases biology.protein Protein biosynthesis Coding region |
| Zdroj: | Gene. 179:157-162 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(96)00420-9 |
| Popis: | The chloramphenicol (Cm)-inducible cat and cmlA genes are regulated by translation attenuation, a regulatory device that modulates mRNA translation. In this form of gene regulation, translation of the CmR coding sequence is prevented by mRNA secondary structure that sequesters its ribosome-binding site (RBS). A translated leader of nine codons precedes the secondary structure, and induction results when a ribosome becomes stalled at a specific site in the leader. Here we demonstrate that the site of ribosome stalling in the leader is selected by a cis effect of the nascent leader peptide on its translating ribosome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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