THE VASOPRESSIN TEST AS AN AID IN THE EVALUATION OF HYPOTHALAMO-PITUITARY-ADRENAL FUNCTION

Autor: Isa Sundholm, H. Hortling, Eva Puupponen
Rok vydání: 2009
Předmět:
Zdroj: Acta Medica Scandinavica. 189:479-484
ISSN: 0001-6101
DOI: 10.1111/j.0954-6820.1971.tb04408.x
Popis: The effect of lysine vasopressin (LVP) on plasma 11-hydroxycorticosteroids (11-OHCS), when administered intramuscularly at 10 p.m., and at one and two hours later has been studied in a series of 164 individuals, 43 of whom served as controls and the others represented groups of patients with hypopituitarism, glucocorticoid-treated patients and other metabolically interesting patients. There was a significantly smaller average rise of 11-OHCS in the hypopituitarism group and in the corticoid-treated groups than in the control group. Oestrogen-treated patients responded normally to LVP. The side-effects caused by the administration of LVP were slight and well tolerated in all patients. In a number of patients the adrenal function was studied with the aid of the 5 hours' intravenous adreno-corticotropic hormone (ACTH) test after the LVP test. The effect of LVP on the eosinophil cells in the blood was smaller than that caused by ACTH in the i.v. test. The LVP test can be used as a convenient screening test of the hypothalamic-adrenal system.
Databáze: OpenAIRE