The Mitochondrion: A Promising Target for Kidney Disease

Autor: Cem Tanriover, Sidar Copur, Duygu Ucku, Ahmet B. Cakir, Nuri B. Hasbal, Maria Jose Soler, Mehmet Kanbay
Přispěvatelé: Institut Català de la Salut, [Tanriover C, Copur S, Ucku D, Cakir AB] Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. [Hasbal NB, Kanbay M] Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. [Soler MJ] Grup de Recerca de Nefrologia i Trasplantament Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2023
Předmět:
Medicaments - Efectes fisiològics
Male Urogenital Diseases::Urologic Diseases::Kidney Diseases [DISEASES]
células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias [ANATOMÍA]
Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores]
Pharmaceutical Science
Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria [ANATOMY]
Other subheadings::/drug effects [Other subheadings]
Other subheadings::Other subheadings::/drug therapy [Other subheadings]
Otros calificadores::/efectos de los fármacos [Otros calificadores]
enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales [ENFERMEDADES]
Ronyons - Malalties - Tractament
Mitocondris
Zdroj: Scientia
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics15020570
Popis: Acute kidney injury; Chronic kidney disease; Mitochondrial dysfunction Lesión renal aguda; Enfermedad renal crónica; Disfunción mitocondrial Lesió renal aguda; Malaltia renal crònica; Disfunció mitocondrial Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and the mitochondria potentially serve as therapeutic targets necessitating further investigation. Alterations in mitochondrial biogenesis, imbalance between fusion and fission processes leading to mitochondrial fragmentation, oxidative stress, release of cytochrome c and mitochondrial DNA resulting in apoptosis, mitophagy, and defects in energy metabolism are the key pathophysiological mechanisms underlying the role of mitochondrial dysfunction in kidney diseases. Currently, various strategies target the mitochondria to improve kidney function and kidney treatment. The agents used in these strategies can be classified as biogenesis activators, fission inhibitors, antioxidants, mPTP inhibitors, and agents which enhance mitophagy and cardiolipin-protective drugs. Several glucose-lowering drugs, such as glucagon-like peptide-1 receptor agonists (GLP-1-RA) and sodium glucose co-transporter-2 (SGLT-2) inhibitors are also known to have influences on these mechanisms. In this review, we delineate the role of mitochondrial dysfunction in kidney disease, the current mitochondria-targeting treatment options affecting the kidneys and the future role of mitochondria in kidney pathology.
Databáze: OpenAIRE
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