Discovery solubility measurement and assessment of small molecules with drug development in mind

Autor:	Jaclyn A, Barrett, Wenzhan, Yang, Suzanne M, Skolnik, Lisa M, Belliveau, Kellyn M, Patros
Rok vydání:	2022
Předmět:	Pharmacology Drug Development Pharmaceutical Preparations Solubility Drug Design Drug Discovery
Zdroj:	Drug Discovery Today. 27:1315-1325
ISSN:	1359-6446
Popis:	Solubility is a key physicochemical property for the success of any drug candidate. Although the methods used and their rationales for determining solubility are subject to project needs and stages along the drug discovery-drug development pipeline, an artificial boundary can exist at the discovery-development interface. This boundary results in less effective solubility knowledge sharing and data integration among scientists in both drug discovery and drug development. Herein, we present a refreshed perspective on solubility. Solubility experimentation is not a one-size-fits-all measurement; instead, we stress the importance of constructing a seamless solubility understanding of a molecule as it progresses from a new chemical entity into a drug product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734cc91c353593c850b4bd8a3dd3df86 https://doi.org/10.1016/j.drudis.2022.01.017 Zobrazit plný text záznamu Full Text from ScienceDirect