Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus
| Autor: | Futoshi Anan, Tsuyoshi Shimomura, Takayuki Masaki, Minoru Fujiki, Tetsunori Saikawa, Hironobu Yoshimatsu |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Hippocampus Cognition Endocrinology Insulin resistance Asian People Japan Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Insulin Hippocampus (mythology) Aged Psychological Tests medicine.diagnostic_test Adiponectin business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Magnetic resonance imaging Fasting Organ Size Middle Aged medicine.disease Magnetic Resonance Imaging Diabetes Mellitus Type 2 Multivariate Analysis Insulin Resistance business Biomarkers hormones hormone substitutes and hormone antagonists Homeostasis |
| Zdroj: | Metabolism. 61:1197-1200 |
| ISSN: | 0026-0495 |
| Popis: | Type 2 diabetes mellitus (DM) is associated with cognitive dysfunction and hippocampus volume. The aim of the present study was to test the hypothesis that the level of the adipocytokine adiponectin correlates with hippocampus volume and insulin resistance in patients with type 2 DM. A total of 45 patients with type 2 DM were divided into two groups: a low adiponectin group and a normal adiponectin group. Hippocampus volume was measured by computer-assisted analysis using a magnetic resonance imaging (MRI) voxel-based specific regional analysis system developed for the study of Alzheimer's disease as the end point for assessment of hippocampus volume. Mean hippocampus volume was lower in the low adiponectin group than in the normal adiponectin group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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