Enhanced baroreflex-mediated inhibition of respiration after muscimol dialysis in the rostroventral medulla
| Autor: | Aidan K. Curran, Cheryl A. Elinsky, James C. Leiter, Daniel Peraza |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Time Factors Swine Physiology Central nervous system Baroreflex Sudden death Phenylephrine chemistry.chemical_compound Physiology (medical) Internal medicine medicine Animals Vasoconstrictor Agents GABA Agonists Medulla Medulla Oblongata Muscimol business.industry Respiration Sudden infant death syndrome Endocrinology medicine.anatomical_structure Animals Newborn chemistry Respiratory Physiological Phenomena Medulla oblongata Breathing business Dialysis |
| Zdroj: | Journal of Applied Physiology. 92:2554-2564 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00895.2001 |
| Popis: | The rostral ventral medulla (RVM) may be important in the control of cardiorespiratory interactions. We hypothesized that inhibition of the RVM would enhance inhibition of breathing associated with transient blood pressure elevations. In 25 piglets 3–16 days of age, we studied the effect of acutely increasing blood pressure, by systemic infusion of phenylephrine, on respiratory activity before and after inhibition of neural activity in the RVM by dialysis of 10 mM muscimol, a GABAA-receptor agonist. Muscimol dialysis through probes that were placed along the ventral medullary surface from ∼1 mm rostral to the facial nucleus to ∼0.5 mm caudal to the facial nucleus augmented the respiratory inhibition associated with acute increases in blood pressure. No similar enhancement of respiratory inhibition after phenylephrine treatment was seen in six control animals that did not receive muscimol dialysis. We conclude that the piglet RVM participates in cardiorespiratory interactions and that dysfunction of homologous regions in the human infant could lead to cardiorespiratory instability and may be involved in the pathogenesis of sudden infant death syndrome. |
| Databáze: | OpenAIRE |
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