Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid
| Autor: | Hidekachi Kurotaki, Soroku Yagihashi, Yasuyoshi Shikama, Tadaharu Osawa, Nobuo Yagihashi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty animal diseases Cellular differentiation Enteroendocrine cell Neuroendocrine differentiation Pathology and Forensic Medicine Paraganglioma mental disorders medicine Humans Thyroid Neoplasms Molecular Biology Paraganglioma Extra-Adrenal biology Hyaline substance Thyroid Chromogranin A Cell Differentiation Cell Biology General Medicine Middle Aged medicine.disease Neurosecretory Systems Carcinoma Papillary nervous system diseases Microscopy Electron medicine.anatomical_structure nervous system Medullary carcinoma biology.protein Female |
| Zdroj: | Virchows Archiv. 443:792-796 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-003-0901-4 |
| Popis: | The presence of neuroendocrine cells is putative in thyroid hyalinizing trabecular tumor (HTT), although this entity requires a differential diagnosis from paraganglioma or medullary carcinoma of the thyroid, due to similarity of the growth pattern of the cells. Here, we present a case of HTT with a mixture of endocrine cells stained positive for somatostatin, chromogranin A and Grimelius' silver impregnation. The histology and results of other immunostainings were consistent with the features typical for HTT. In the world literature to date, only two cases of HTT with endocrine cells, including the current case, have been reported. Nevertheless, the cases may indicate the diversified differentiation of cells in HTT and may, in part, account for the resemblance of HTT to paraganglioma and medullary carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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