The functional role of surface molecules on extracellular vesicles in cancer, autoimmune diseases, and coagulopathy
| Autor: | Chor Sang Chim, James C. B. Li, Katy C. K. Lam, Moses K. N. Lam, Godfrey Chi-Fung Chan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Functional role Immunology Cancer Clinical settings Cell Biology Blood Coagulation Disorders Biology medicine.disease Extracellular vesicles Autoimmune Diseases Cell biology Extracellular Vesicles 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neoplasms 030220 oncology & carcinogenesis medicine Coagulopathy Humans Immunology and Allergy Signal Transduction |
| Zdroj: | Journal of Leukocyte Biology. 108:1565-1573 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.3mr0420-067r |
| Popis: | Extracellular vesicles (EVs) are nanosized particles that have emerged as mediators for intercellular communication in physiologic and pathologic conditions. EVs carry signaling information on their bilipid membrane as well as cargo within, allowing them to perform a wide range of biologic processes and contribute to pathophysiologic roles in a wide range of diseases, including cancer, autoimmune diseases and coagulopathy. This review will specifically address the function of surface molecules on EVs under normal and diseased conditions, as well as their potential to emerge as therapeutic targets in clinical settings, and the importance of further research on the surface topography of EVs. |
| Databáze: | OpenAIRE |
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