Hyperkeratosis in Flegel's disease
| Autor: | Veronika Burmeister, Rajagopala Swaminathan |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Pathology
medicine.medical_specialty Hyperkeratosis Mucocutaneous zone Acanthosis Leg Dermatoses Hyperkeratosis lenticularis perstans Tongue Medicine Humans Parakeratosis Isotretinoin Aged medicine.diagnostic_test business.industry General Medicine Keratosis medicine.disease Dermatology medicine.anatomical_structure Skin biopsy Microscopy Electron Scanning Female medicine.symptom Epidermis business medicine.drug |
| Zdroj: | JAMA. 254(6) |
| ISSN: | 0098-7484 |
| Popis: | Hyperkeratosis lenticularis perstans was first described by Flegel1in 1958. It may rightly be redefined as an autosomal dominant mucocutaneous syndrome of variable expressivity, characterized by an aberration in the keratinization process. A 67-year-old woman presented with numerous asymptomatic keratotic lesions, confined to the anterior aspect of the legs and the dorsa of the feet. These skin-colored papules varied in size from 1 to 4 mm in diameter. Other manifestations were palmar pits and mucosal lesions on the tongue. The patient was treated with vitamin A (Aquasol A) and topical tretinoin 0.01% gel (Retin-A), with some response. The lack of patient compliance ruled out the use of isotretinoin (Accutane). A specimen from a skin biopsy was examined under a light microscope and displayed massive hyperkeratosis and spotty parakeratosis, with the granular layer being absent in most areas except in the relatively normal margin. There was some irregular acanthosis in |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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