Increased Prevalence of Calcium Transients across the Dendritic Arbor during Place Field Formation
| Autor: | Michael D. Adoff, Mark E. J. Sheffield, Daniel A. Dombeck |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Mice 129 Strain Place cell Action Potentials Hippocampus Mice Transgenic Biology Hippocampal formation Mice 03 medical and health sciences Organ Culture Techniques 0302 clinical medicine Calcium imaging Prevalence Animals CA1 Region Hippocampal Dendritic spike Neuronal Plasticity General Neuroscience Depolarization Long-term potentiation Dendrites Mice Inbred C57BL 030104 developmental biology Synaptic plasticity Calcium Neuroscience Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 96:490-504.e5 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2017.09.029 |
| Popis: | Hippocampal place cell ensembles form a cognitive map of space during exposure to novel environments. However, surprisingly little evidence exists to support the idea that synaptic plasticity in place cells is involved in forming new place fields. Here we used high-resolution functional imaging to determine the signaling patterns in CA1 soma, dendrites, and axons associated with place field formation when mice are exposed to novel virtual environments. We found that putative local dendritic spikes often occur prior to somatic place field firing. Subsequently, the first occurrence of somatic place field firing was associated with widespread regenerative dendritic events, which decreased in prevalence with increased novel environment experience. This transient increase in regenerative events was likely facilitated by a reduction in dendritic inhibition. Since regenerative dendritic events can provide the depolarization necessary for Hebbian potentiation, these results suggest that activity-dependent synaptic plasticity underlies the formation of many CA1 place fields. |
| Databáze: | OpenAIRE |
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