Stage III and Metastatic Lymph Node Ratio Are the only Independent Prognostic Factors in Colorectal Signet-ring Cell Carcinoma Patients
| Autor: | Renato Costi, Francesco Leonardi, Pellegrino Crafa, Andrea Morini, Alfredo Annicchiarico, Andrea Romboli, Paolo Dell'Abate, Matteo Riccò, Edoardo Virgilio |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Colorectal cancer Lymphovascular invasion Colorectal Signet Ring Cell Carcinoma Malignancy Disease-Free Survival Internal medicine Signet ring cell carcinoma medicine Humans Neoplasm Metastasis Stage (cooking) Lymph node Aged Neoplasm Staging Univariate analysis business.industry General Medicine Prognosis medicine.disease medicine.anatomical_structure Female Colorectal Neoplasms business Carcinoma Signet Ring Cell Lymph Node Ratio |
| Zdroj: | Anticancer Research. 40:7127-7134 |
| ISSN: | 1791-7530 0250-7005 |
| Popis: | Background/aim Signet-ring cell carcinoma (SRCC) is an uncommon histological variant of colorectal cancer (CRC). Knowledge is scarce due to its rarity. Our aim was to better evaluate the clinicopathologic and prognostic features of this little-known malignancy. Patients and methods Thirty-nine consecutive patients with non-metastatic colorectal SRCC undergoing curative resection at University Hospital of Parma between 2000 and 2018 were examined in this retrospective analysis. Results Mean overall (OS) and disease-free survival (DFS) were 33.6 and 31.5 months, respectively. At univariate analysis, the lymph-related parameters (nodal status, Stage III, metastatic lymph node ratio and lymphovascular invasion) were significantly associated with shorter OS and poorer DFS. At multivariate analysis, Stage III and a metastatic lymph node ratio ≥25% were found to be the only independent prognostic factors significantly correlated with worse OS and DFS. Conclusion Nodal and lymphatic status should be carefully pondered when planning the most appropriate management of patients with colorectal SRCC. |
| Databáze: | OpenAIRE |
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