Agrocin 108 is a 5'-cytidine nucleotide bacteriocin containing a carbocyclic phosphoryl-ascorbate group
| Autor: | Scott C Donner, Christopher M Elvin, Graham P. Jones, Maarten H. Ryder, Robert E. Asenstorfer, Max E. Tate |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cyclopentenone Magnetic Resonance Spectroscopy Stereochemistry Molecular Conformation Cytidine Microbial Sensitivity Tests Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Bacteriocins Bacteriocin Formaldehyde Drug Discovery Electrophoresis Paper Nucleotide Pharmacology chemistry.chemical_classification Xylose Bacteria biology Strain (chemistry) Nuclear magnetic resonance spectroscopy Rhizobium rhizogenes biology.organism_classification 030104 developmental biology chemistry Two-dimensional nuclear magnetic resonance spectroscopy Rhizobium |
| Zdroj: | The Journal of Antibiotics. 71:438-446 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/s41429-017-0014-y |
| Popis: | Agrocin 108 is a 3'-O-β-D-xylopyranosyl-cytidine-5'-O-phosphodiester of an ascorbate-carbocyclic cyclopentenone analogue, with bacteriocin-like properties. This bacteriocin exhibits orders of magnitude greater than the inhibition zone diameter towards the indicator strain than either ampicillin or streptomycin. It has been isolated from cultures of Rhizobium rhizogenes strain K108. The structure of the agrocin 108 without detail, has been previously published. We now report a detailed structure elucidation, including the hitherto undetermined residual 5'-phospho-diester fragment by a combination of 1D and 2D NMR studies at various pH values in H2O/D2O, high resolution MS, pKa determination, and chemical degradation. |
| Databáze: | OpenAIRE |
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