Subthalamic beta oscillations correlate with dopaminergic degeneration in experimental parkinsonism

Autor: Andreas Kupsch, Jens K. Haumesser, Christoph van Riesen, Daniel Harnack, Johanna Kühn, Vadim V. Nikulin, Andrea A. Kühn, Franziska Pellegrini, Maximilian H. Beck, Wolf-Julian Neumann, Jennifer Altschüler
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Parkinson's disease
pathology [Dopaminergic Neurons]
Deep Brain Stimulation
physiopathology [Neostriatum]
Striatum
pathology [Parkinsonian Disorders]
0302 clinical medicine
Basal ganglia
Beta oscillations
Movement Disorders
pathology [Motor Cortex]
Neurodegeneration
Motor Cortex
pathology [Nerve Degeneration]
Electroencephalography
Subthalamic nucleus
medicine.anatomical_structure
Treatment Outcome
Neurology
Primary motor cortex
Motor cortex
chemically induced [Parkinsonian Disorders]
03 medical and health sciences
Hydroxydopamines
Developmental Neuroscience
Parkinsonian Disorders
Subthalamic Nucleus
medicine
Animals
ddc:610
Pars compacta
business.industry
Dopaminergic Neurons
physiopathology [Subthalamic Nucleus]
pathology [Movement Disorders]
medicine.disease
Electrophysiological Phenomena
Rats
Neostriatum
030104 developmental biology
Nerve Degeneration
business
Beta Rhythm
Neuroscience
030217 neurology & neurosurgery
Zdroj: Experimental neurology 335, 113513-(2021). doi:10.1016/j.expneurol.2020.113513
ISSN: 1090-2430
DOI: 10.1016/j.expneurol.2020.113513
Popis: Excessive beta activity has been shown in local field potential recordings from the cortico-basal ganglia loop of Parkinson's disease patients and in its various animal models. Recent evidence suggests that enhanced beta oscillations may play a central role in the pathophysiology of the disorder and that beta activity may be directly linked to the motor impairment. However, the temporal evolution of exaggerated beta oscillations during the ongoing dopaminergic neurodegeneration and its relation to the motor impairment and histological changes are still unknown. We investigated motor behavioral, in-vivo electrophysiological (subthalamic nucleus, motor cortex) and histological changes (striatum, substantia nigra compacta) 2, 5, 10 and 20–30 days after a 6-hydroxydopamine injection into the medial forebrain bundle in Wistar rats. We found strong correlations between subthalamic beta power and motor impairment. No correlation was found for beta power in the primary motor cortex. Only subthalamic but not cortical beta power was strongly correlated with the histological markers of the dopaminergic neurodegeneration. Significantly increased subthalamic beta oscillations could be detected before this increase was found in primary motor cortex. At the latest observation time point, a significantly higher percentage of long beta bursts was found. Our study is the first to show a strong relation between subthalamic beta power and the dopaminergic neurodegeneration. Thus, we provide additional evidence for an important pathophysiological role of subthalamic beta oscillations and prolonged beta bursts in Parkinson's disease.
Databáze: OpenAIRE
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