Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures

Autor:	C. Chandra Kumar, Alan Bronnenkant, Bernard R. Neustadt, T. Nechuta, Lydia Armstrong, Lindo Neil A, Arthur Wu, Elizabeth M. Smith
Rok vydání:	1999
Předmět:	Stereochemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science Biochemistry Set (abstract data type) chemistry.chemical_compound Structure-Activity Relationship Isomerism Drug Discovery Receptors Vitronectin Molecular Biology Structure (mathematical logic) Biphenyl biology Molecular Structure Organic Chemistry Biphenyl Compounds Construct (python library) Combinatorial chemistry Kinetics chemistry Databases as Topic Drug Design biology.protein Molecular Medicine Vitronectin
Zdroj:	Bioorganicmedicinal chemistry letters. 8(17)
ISSN:	0960-894X
Popis:	A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733d06f016fb2c7d9cf9c4cdd96ea3b2 https://pubmed.ncbi.nlm.nih.gov/9873548 Zobrazit plný text záznamu Full Text from ScienceDirect