Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease
| Autor: | Pricila Girardi, Julia P. Genro, Thais Fernanda Dornelles, Marcelo Arndt, Verônica Contini, Camile Wunsch |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Population Disease risk score 030204 cardiovascular system & hematology association study Polymorphism Single Nucleotide Diseases of the endocrine glands. Clinical endocrinology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine t2dm medicine Humans Genetic Predisposition to Disease Allele education Genetic Association Studies Aged education.field_of_study Framingham Risk Score business.industry Haplotype nutritional and metabolic diseases Type 2 Diabetes Mellitus Middle Aged RC648-665 medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 Cardiovascular Diseases Case-Control Studies cad Female business Transcription Factor 7-Like 2 Protein TCF7L2 Brazil Diabetic Angiopathies coronary artery disease |
| Zdroj: | Endocrine Regulations, Vol 53, Iss 1, Pp 1-7 (2019) |
| ISSN: | 1336-0329 |
| DOI: | 10.2478/enr-2019-0001 |
| Popis: | Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk. Methods. A sample of six hundred and forty-seven patients that underwent the coronary angiography in a Cardiac Catheterization Lab was evaluated. The patients were investigated for the presence of T2DM and coronary stenosis. The TCF7L2 polymorphisms were genotyped by real-time PCR and the haplotype analysis was performed with the MLOCUS software. All genetic tests were carried out by considering the haplotype combinations in patients divided into three groups: 0 – carrying none disease risk allele, 1 – carrying one or two risk alleles and 2 – carrying three or four risk alleles. Results. No significant associations between TCF7L2 risk haplotypes and the presence of T2DM or CAD were detected. Conclusions. Our results indicate that the TCF7L2 rs12255372 and rs7903146 polymorphisms do not influence T2DM in Brazilian patients with the high risk for CAD. Therefore, we assume that these variants may only be relevant for a specific subgroup of T2DM patients or some particular human population. |
| Databáze: | OpenAIRE |
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