The utility of stem cells in pediatric urinary bladder regeneration

Autor: Yong Chao Ma, Vasil Galat, Philip M. Iannaccone, Arun K. Sharma, Matthew I. Bury
Rok vydání: 2017
Předmět:
0301 basic medicine
Pathology
medicine.medical_specialty
Induced Pluripotent Stem Cells
Urinary Bladder
Urology
Bone Marrow Cells
Regenerative Medicine
urologic and male genital diseases
Bladder Urothelium
03 medical and health sciences
Animals
Humans
Regeneration
Medicine
Hedgehog Proteins
Urinary Bladder
Neurogenic
Urothelium
Induced pluripotent stem cell
Spinal Dysraphism
Neurogenic bladder dysfunction
Urinary bladder
Tissue Engineering
Tissue Scaffolds
business.industry
Regeneration (biology)
Bone Marrow Stem Cell
Cell Differentiation
Mesenchymal Stem Cells
Muscle
Smooth
medicine.disease
female genital diseases and pregnancy complications
Phenotype
030104 developmental biology
medicine.anatomical_structure
Pediatrics
Perinatology and Child Health
Stem cell
business
Signal Transduction
Stem Cell Transplantation
Zdroj: Pediatric Research. 83:258-266
ISSN: 1530-0447
0031-3998
DOI: 10.1038/pr.2017.229
Popis: Pediatric patients with a neurogenic urinary bladder, caused by developmental abnormalities including spina bifida, exhibit chronic urological problems. Surgical management in the form of enterocystoplasty is used to enlarge the bladder, but is associated with significant clinical complications. Thus, alternative methods to enterocystoplasty have been explored through the incorporation of stem cells with tissue engineering strategies. Within the context of this review, we will examine the use of bone marrow stem cells and induced pluripotent stem cells (iPSCs), as they relate to bladder regeneration at the anatomic and molecular levels. The use of bone marrow stem cells has demonstrated significant advances in bladder tissue regeneration as multiple aspects of bladder tissue have been recapitulated including the urothelium, bladder smooth muscle, vasculature, and peripheral nerves. iPSCs, on the other hand, have been well characterized and used in multiple tissue-regenerative settings, yet iPSC research is still in its infancy with regards to bladder tissue regeneration with recent studies describing the differentiation of iPSCs to the bladder urothelium. Finally, we examine the role of the Sonic Hedgehog signaling cascade that mediates the proliferative response during regeneration between bladder smooth muscle and urothelium. Taken together, this review provides a current, comprehensive perspective on bladder regeneration.
Databáze: OpenAIRE
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