Value of plasma neutrophil gelatinase-associated lipocalin (NGAL) in distinguishing between acute kidney injury (AKI) and chronic kidney disease (CKD)
| Autor: | Veysel Oncul, Şeref Kerem Çorbacıoğlu, Hüseyin Uzunosmanoğlu, Murat Guvendi, Yunsur Çevik, Seda Dagar, Tuba Şafak, Emine Akinci |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030232 urology & nephrology Urology 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Chronic kidney disease medicine Prospective cohort study Neutrophil gelatinase-associated lipocalin (NGAL) Kidney business.industry Emergency department Acute kidney injury lcsh:Medical emergencies. Critical care. Intensive care. First aid Venous blood lcsh:RC86-88.9 medicine.disease female genital diseases and pregnancy complications Neutrophil gelatinase-associated lipocalin medicine.anatomical_structure Biomarker (medicine) Original Article business Kidney disease |
| Zdroj: | Turkish Journal of Emergency Medicine, Vol 17, Iss 3, Pp 85-88 (2017) Turkish Journal of Emergency Medicine |
| ISSN: | 2452-2473 |
| Popis: | Objective: In this study, we aimed to determine whether plasma NGAL levels could be used as a biomarker for distinguishing between AKI and CKD in emergency medicine. Materials and methods: This prospective study was conducted at the ED of a training and research hospital over a six-month period in 2015. Three groups were defined: an AKI group – defined as a new onset of at least a 1.5-fold or ≥0.3 mg increment increase of SCr values from the normal baseline, a stable CKD group – only included presence of stages 2 through 4 of CKD according to the National Kidney Foundation's KDIGO 2012, and a control group. After the initial evaluation of patients, venous blood samples were taken for routine biochemical, counter blood cell, and plasma NGAL measurement at admission. Results: A total of 25 patients with AKI, 22 patients with stable CKD, and 22 control subjects were enrolled. Level of plasma NGAL in AKI group was higher than those of the stable CKD group (median: 794 ng/ml IQR: 317–1300 & 390 ng/ml IQR: 219–664, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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