Effects of indomethacin on renal function in normotensive patients with chronic glomerulonephritis with preserved renal function
| Autor: | Erling B. Pedersen, S. S. Sørensen, C. B. Nielsen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Vasopressin medicine.medical_specialty Renal Plasma Flow Indomethacin Clinical Biochemistry Natriuresis Renal function Blood Pressure Kidney Excretion chemistry.chemical_compound Glomerulonephritis Heart Rate Internal medicine Renin–angiotensin system medicine Humans Aldosterone General Medicine Middle Aged Angiotensin II Hormones Diuresis Endocrinology chemistry Renal blood flow Female Endothelin receptor Glomerular Filtration Rate |
| Zdroj: | Nielsen, C B, Sørensen, S S & Pedersen, E B 1994, ' Effects of indomethacin on renal function in normotensive patients with chronic glomerulonephritis with preserved renal function ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 54 (7), pp. 523-9 . |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365519409088564 |
| Popis: | Thirteen normotensive patients with biopsy verified chronic glomerulonephritis (GN) with preserved renal function and 12 healthy control subjects (CS) were studied before and during prostaglandin synthesis inhibition by indomethacin. Glomerular filtration rate (GFR), renal plasma flow (RPF), urinary output (V), sodium excretion (UNa V), fractional lithium excretion (FELi), plasma levels of angiotensin II (Ang II), aldosterone (Aldo), atrial natiuretic peptide (ANP), arginine vasopressin (AVP) and endothelin (ir-ET) and urinary excretion rates of PGE2, mean blood pressure (MBP) and heart rate (HB) were determined on two separate occasions at least 7 days apart. During basal conditions without indomethacin administration no significant differences were found between the two groups. Indomethacin administration (100 mg 12 h and 1 h before clearance investigations) resulted in significant and almost identical decreases in GFR, RPF, V, UNa V, FELi and HR and increases in MBP in both the GN group and the CS group. It is concluded that normotensive patients with a biopsy verified chronic glomerulonephritis but with preserved renal function and without nephrotic syndrome have no increased risk of acute deterioration of renal function during administration of a non-steroidal anti-inflammatory drug compared with healthy control subjects. |
| Databáze: | OpenAIRE |
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