Pharmacological and somatic treatment effects on suicide in adults: A systematic review and meta-analysis
| Autor: | Mark Olfson, Daniel Trujillo Diaz, Anubhav Kidambi, Samuel T. Wilkinson, Michael H. Bloch, Zachary W Rupp, José M. Flores, T Greg Rhee, Victor J Avila-Quintero, Karina L Ramirez |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Suicide Prevention medicine.medical_specialty Bipolar Disorder Lithium (medication) business.industry Odds ratio General Medicine medicine.disease Placebo Transcranial Direct Current Stimulation Psychiatry and Mental health Clinical Psychology Mood Antimanic Agents Internal medicine Meta-analysis medicine Lithium Compounds Humans Bipolar disorder business Clozapine Depression (differential diagnoses) medicine.drug |
| Zdroj: | Depression and anxietyREFERENCES. 39(2) |
| ISSN: | 1520-6394 |
| Popis: | BACKGROUND Suicide is a public health crisis. We conducted a systematic review and meta-analysis of the effects of psychopharmacologic and somatic therapies on suicide risk. METHODS A systematic search of MEDLINE for studies evaluating the effects of pharmacologic (excluding antidepressants) or somatic interventions on suicide risk was conducted. Studies were included if they used a comparison group, reported on suicide death, assessed a psychopharmacological or somatic intervention, and included adults. Study quality was assessed using the Newcastle-Ottawa scale. Fifty-seven studies were included from 2940 reviewed citations. RESULTS In bipolar disorder, lithium was associated with a reduction in the odds of suicide compared to active controls (odds ratio [OR] = .58, p = .005; k = 12) and compared to placebo/no lithium (OR = .46, p = .009; k = 9). In mixed diagnostic samples, lithium was associated with a reduction in the odds of suicide compared to placebo/no lithium (OR = .27, p |
| Databáze: | OpenAIRE |
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