Aging and Immortality in a Cell Proliferation Model
| Autor: | S.A. Trugman, K.B. Blagoev, Sidney Redner, Tibor Antal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Statistics and Probability
Senescence DNA Replication Cell division Cell Survival Cell Population FOS: Physical sciences Biology 01 natural sciences General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0103 physical sciences Cell Behavior (q-bio.CB) medicine Humans Physics - Biological Physics 010306 general physics education Condensed Matter - Statistical Mechanics Cellular Senescence 030304 developmental biology 0303 health sciences education.field_of_study General Immunology and Microbiology Statistical Mechanics (cond-mat.stat-mech) Cell Death Models Genetic Cell growth Applied Mathematics DNA replication General Medicine DNA Telomere Cell biology medicine.anatomical_structure Biological Physics (physics.bio-ph) Modeling and Simulation FOS: Biological sciences Quantitative Biology - Cell Behavior General Agricultural and Biological Sciences Cell aging Cell Division Mathematics |
| Popis: | We investigate a model of cell division in which the length of telomeres within the cell regulate their proliferative potential. At each cell division the ends of linear chromosomes change and a cell becomes senescent when one or more of its telomeres become shorter than a critical length. In addition to this systematic shortening, exchange of telomere DNA between the two daughter cells can occur at each cell division. We map this telomere dynamics onto a biased branching diffusion process with an absorbing boundary condition whenever any telomere reaches the critical length. As the relative effects of telomere shortening and cell division are varied, there is a phase transition between finite lifetime and infinite proliferation of the cell population. Using simple first-passage ideas, we quantify the nature of this transition. 6 pages, 1 figure, 2-column revtex4 format; version 2: final published form; contains various improvements in response to referee comments |
| Databáze: | OpenAIRE |
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