Pregnancy outcomes following systemic prenatal acyclovir exposure: Conclusions from the international acyclovir pregnancy registry, 1984-1999
| Autor: | E. Russell Alexander, Robbin Reiff-Eldridge, Alice D. White, Zane A. Brown, José F. Cordero, Katherine M. Stone, Elizabeth Andrews |
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| Rok vydání: | 2004 |
| Předmět: |
Embryology
medicine.medical_specialty Population Acyclovir Antiviral Agents Pregnancy Epidemiology medicine Humans Aciclovir education Pregnancy outcomes Maternal-Fetal Exchange Pregnancy registry Fetus education.field_of_study Obstetrics business.industry Pregnancy Outcome Abnormalities Drug-Induced General Medicine medicine.disease Pediatrics Perinatology and Child Health Gestation Female business Developmental Biology medicine.drug |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 70:201-207 |
| ISSN: | 1542-0760 1542-0752 |
| Popis: | BACKGROUND Oral acyclovir is commonly used for genital herpes and other herpesvirus infections. Data on potential fetal risk are extremely limited. From 1984 to 1998, the Acyclovir in Pregnancy Registry monitored birth outcomes of women exposed to oral or intravenous acyclovir during pregnancy. This report describes the final results. METHODS The registry was publicized to health care providers most likely to diagnose pregnancy; providers called the registry telephone number, then mailed in a brief questionnaire. Pregnancy outcomes were categorized either as outcomes with birth defects or outcomes without birth defects, subcategorized as live births, spontaneous pregnancy losses (including stillbirths), and induced abortions. Birth defects were defined using a modification of the CDC definition for birth defects surveillance systems. Observed rates were compared to the rate (3.2%) of birth defects expected in the general population. RESULTS Between June 1, 1984 and June 30, 1998, 1695 pregnancies exposed to oral or IV acyclovir were registered; 461 (27%) were lost to follow-up. A total of 1234 pregnancies in 24 countries were followed, with a total of 1246 outcomes. Among 1246 pregnancy outcomes, 756 involved acyclovir exposure in the first trimester, 197 in the second trimester, and 291 in the third trimester. Among live births with first trimester acyclovir exposure, risk of birth defects was 19 of 596 (3.2%; 95% CI, 2.0–5.0%). No unusual defects or pattern of defects were apparent. CONCLUSIONS The observed rates and types of birth defects for pregnancies exposed to acyclovir did not differ significantly from those in the general population. Birth Defects Research (Part A), 2004. Published 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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