Post-translational modification of RelA(p65) NF-κB
| Autor: | Neil D. Perkins, K. J. Campbell |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Inflammation
NF-kappa B Transcription Factor RelA Apoptosis Cell Differentiation NF-κB Stimulation Biology Models Biological Biochemistry chemistry.chemical_compound Immune system chemistry Posttranslational modification Cancer research Animals Humans Phosphorylation Dimerization Protein Processing Post-Translational Transcription factor Reprogramming Cell Division Function (biology) |
| Zdroj: | Biochemical Society Transactions. 32:1087-1089 |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst0321087 |
| Popis: | Stimulation with diverse agents activates the NF-kappaB (nuclear factor kappaB) transcription factor, affecting inflammatory and immune responses, proliferation, differentiation, apoptosis and tumourigenesis. Determining how NF-kappaB elicits such distinct responses is essential to understanding NF-kappaB function in diseased tissues. Recent developments illustrating that post-translational modification of NF-kappaB subunits influences their nuclear role are discussed. These observations suggest that diagnosis and new therapies based on reprogramming NF-kappaB activity could be more efficient than total NF-kappaB inhibition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|