Reduced oxygen extraction efficiency in sickle cell anemia patients with evidence of cerebral capillary shunting
Autor: | Adetola A. Kassim, Meher R. Juttukonda, Lori C. Jordan, Niral J Patel, Larry T Davis, Spencer L. Waddle, Sumit Pruthi, Chelsea A Lee, Manus J. Donahue |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Capillary action media_common.quotation_subject Contrast Media Anemia Sickle Cell Coronary Angiography 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine otorhinolaryngologic diseases Humans Medicine Contrast (vision) media_common medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Cerebral Infarction Original Articles medicine.disease Magnetic Resonance Imaging White Matter Sickle cell anemia Hyperintensity Capillaries Oxygen Shunting Neurology Cerebral blood flow Cerebrovascular Circulation Cardiology Arterial blood Female Spin Labels Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
Zdroj: | J Cereb Blood Flow Metab |
ISSN: | 1559-7016 0271-678X |
Popis: | Arterial spin labeling (ASL) magnetic resonance imaging (MRI) utilizes arterial blood water as an endogenous contrast agent to provide a quantitative measure of cerebral blood flow (CBF). Recently, hyperintense signal within dural venous sinuses in ASL images of sickle cell anemia (SCA) patients has been shown to be consistent with elevated flow velocities and may indicate capillary shunting and reduced oxygen extraction. Here, we performed oxygen extraction fraction (OEF) and CBF measurements in adults (cumulative n = 114) with ( n = 69) and without ( n = 45) SCA to test the hypothesis that hyperintense venous ASL signal is associated with reduced OEF. Higher categorical scores of shunting on ASL MRI were associated with lower OEF in participants with silent cerebral infarcts or white matter hyperintensities ( p = 0.003), but not in those without lesions ( p = 0.551). These findings indicate that venous hyperintense signal in ASL images in SCA patients may represent a marker of capillary-level disturbances in oxygen exchange efficiency and small vessel pathology. |
Databáze: | OpenAIRE |
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